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Genes and Nutrition

, Volume 3, Issue 3–4, pp 167–171

First Online: 26 November 2008Received: 08 October 2008Accepted: 12 November 2008DOI: 10.1007-s12263-008-0095-0

Cite this article as: McKay, J.A., Adriaens, M.E., Ford, D. et al. Genes Nutr 2008 3: 167. doi:10.1007-s12263-008-0095-0

Abstract

DNA methylation occurs at CpG dinucleotide sites within the genome and is recognised as one of the mechanisms involved in regulation of gene expression. CpG sites are relatively underrepresented in the mammalian genome, but occur densely in regions called CpG islands CGIs. CGIs located in the promoters of genes inhibit transcription when methylated by impeding transcription factor binding. Due to the malleable nature of DNA methylation, environmental factors are able to influence promoter CGI methylation patterns and thus influence gene expression. Recent studies have provided evidence that nutrition and other environmental exposures can cause altered CGI methylation but, with a few exceptions, the genes influenced by these exposures remain largely unknown. Here we describe a novel bioinformatics approach for the analysis of gene expression microarray data designed to identify regulatory sites within promoters of differentially expressed genes that may be influenced by changes in DNA methylation.

KeywordsBioinformatics CpG islands DNA methylation Gene expression In silico promoter analysis Transcription factor binding sites  Download fulltext PDF



Autor: J. A. McKay - M. E. Adriaens - D. Ford - C. L. Relton - C. T. A. Evelo - J. C. Mathers

Fuente: https://link.springer.com/







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