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ISRN Organic ChemistryVolume 2011 2011, Article ID 919102, 11 pages

Research ArticleDepartment of Organic Chemistry, Maria Curie-Skłodowska University, 33-Gliniana Street, 20-614 Lublin, Poland

Received 27 February 2011; Accepted 24 March 2011

Academic Editors: B. Das and B.-E. Yingyongnarongkul

Copyright © 2011 Katarzyna Kielar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

General approach to the synthesis of prochiral precursors of chiral atropisomeric biaryls based on several complementary methods has been developed. Biaryls were obtained in good to excellent yields depending on their structure and selected method of synthesis. Furthermore, we demonstrate a possibility of utilisation of the obtained compounds possessing 2 or 3 ortho substituents around the aryl-aryl bond in direct and directed arylation reaction leading through transition metal-mediated C–H bond activation to atropisomeric compounds.





Autor: Katarzyna Kielar, Oleg M. Demchuk, and K. Michał Pietrusiewicz

Fuente: https://www.hindawi.com/



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