Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine ToxicityReportar como inadecuado

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Journal of Toxicology - Volume 2014 2014, Article ID 839597, 5 pages -

Research ArticleDepartment of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Received 2 July 2014; Revised 25 August 2014; Accepted 25 August 2014; Published 3 September 2014

Academic Editor: Brad Upham

Copyright © 2014 Seyed Jalal Hosseinimehr and Seyed Amir Hossein Hosseini. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by

I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell HFFF2 were treated with

I and-or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide MTT assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by

I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against

I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy.

Autor: Seyed Jalal Hosseinimehr and Seyed Amir Hossein Hosseini



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