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Theoretical Biology and Medical Modelling

, 5:16

First Online: 30 July 2008Received: 07 July 2008Accepted: 30 July 2008DOI: 10.1186-1742-4682-5-16

Cite this article as: Biro, J.C. Theor Biol Med Model 2008 5: 16. doi:10.1186-1742-4682-5-16


BackgroundThere is a 3-fold redundancy in the Genetic Code; most amino acids are encoded by more than one codon. These synonymous codons are not used equally; there is a Codon Usage Bias CUB. This article will provide novel information about the origin and evolution of this bias.

ResultsCodon Usage Bias CUB, defined here as deviation from equal usage of synonymous codons was studied in 113 species. The average CUB was 29.3 ± 1.1% S.E.M, n = 113 of the theoretical maximum and declined progressively with evolution and increasing genome complexity. A Pan-Genomic Codon Usage Frequency CUF Table was constructed to describe genome-wide relationships among codons. Significant correlations were found between the number of synonymous codons and i the frequency of the respective amino acids ii the size of CUB. Numerous, statistically highly significant, internal correlations were found among codons and the nucleic acids they comprise. These strong correlations made it possible to predict missing synonymous codons wobble bases reliably from the remaining codons or codon residues.

ConclusionThe results put the concept of -codon bias- into a novel perspective. The internal connectivity of codons indicates that all synonymous codons might be integrated parts of the Genetic Code with equal importance in maintaining its functional integrity.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4682-5-16 contains supplementary material, which is available to authorized users.

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Autor: Jan C Biro


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