Recurrent Evolution of Melanism in South American FelidsReportar como inadecuado

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Morphological variation in natural populations is a genomic test bed for studying the interfacebetween molecular evolution and population genetics, but some of the most interestingquestions involve non-model organisms that lack well annotated reference genomes. Manyfelid species exhibit polymorphism for melanism but the relative roles played by geneticdrift, natural selection, and interspecies hybridization remain uncertain. We identify mutationsof Agouti signaling protein ASIP or the Melanocortin 1 receptor MC1R as independentcauses of melanism in three closely related South American species: the pampas catLeopardus colocolo, the kodkod Leopardus guigna, and Geoffroy’s cat Leopardus geoffroyi.To assess population level variation in the regions surrounding the causative mutationswe apply genomic resources from the domestic cat to carry out clone-based captureand targeted resequencing of 299 kb and 251 kb segments that contain ASIP and MC1R,respectively, from 54 individuals 13–21 per species, achieving enrichment of ~500–2500-fold and ~150x coverage. Our analysis points to unique evolutionary histories for each ofthe three species, with a strong selective sweep in the pampas cat, a distinctive but shortmelanism-specific haplotype in the Geoffroy’s cat, and reduced nucleotide diversity for bothancestral and melanism-bearing chromosomes in the kodkod. These results reveal an importantrole for natural selection in a trait of longstanding interest to ecologists, geneticists,and the lay community, and provide a platform for comparative studies of morphological variationin other natural populations.Nota general

Artículo de publicación ISI

Autor: Schneider, Alexsandra; - Henegar, Corneliu; - Day, Kenneth; - Absher, Devin; - Napolitano, Constanza; - Silveira, Leandro; - Davi



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