Hidden IgG Antibodies to the Tumor-Associated Thomsen-Friedenreich Antigen in Gastric Cancer Patients: Lectin Reactivity, Avidity, and Clinical RelevanceReportar como inadecuado




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BioMed Research International - Volume 2017 2017, Article ID 6097647, 11 pages - https:-doi.org-10.1155-2017-6097647

Research ArticleDepartment of Oncology and Immunology, National Institute for Health Development, Hiiu 42, 11619 Tallinn, Estonia

Correspondence should be addressed to Kersti Klaamas

Received 26 July 2016; Accepted 4 January 2017; Published 21 February 2017

Academic Editor: Franco M. Buonaguro

Copyright © 2017 Oleg Kurtenkov and Kersti Klaamas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Natural antibodies to the tumor-associated Thomsen-Friedenreich antigen TF are related to tumor immunosurveillance and cancer patients’ survival. Hidden IgG antibodies HAbs to TF, their lectin reactivity, avidity, and clinical relevance were studied. HAbs were present in cancer patients and controls. A decreased level of IgG HAbs was detected in cancer. The HAbs level positively correlated with the sialospecific SNA lectin binding in purified total IgG tIgG in donors and cancer patients, indicating that HAbs are higher sialylated. The avidity of anti-TF IgG in tIgG samples was lower in cancer patients while no difference in the avidity of free anti-TF IgG was established. A negative correlation between the avidity of anti-TF IgG in tIgG and SNA binding in both groups was observed . The HAbs level negatively correlated with the anti-TF IgG avidity in tIgG only in donors . Changes in the level of HAbs and Abs avidity showed a rather good stage- and gender-dependent diagnostic accuracy. Cancer patients with a lower anti-TF IgG avidity in tIgG showed a benefit in survival. Thus the TF-specific HAbs represent a particular subset of anti-TF IgG that differ from free serum anti-TF IgG in SNA reactivity, avidity, diagnostic potential, and relation to survival.





Autor: Oleg Kurtenkov and Kersti Klaamas

Fuente: https://www.hindawi.com/



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