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Purinergic Signalling

, Volume 3, Issue 4, pp 249–253

First Online: 12 September 2007Received: 23 May 2007Accepted: 02 August 2007DOI: 10.1007-s11302-007-9070-2

Cite this article as: Markwardt, F. Purinergic Signalling 2007 3: 249. doi:10.1007-s11302-007-9070-2


After the primary structure of P2X receptors had been identified, their function had to be characterized on the molecular level. Since these ligand-gated ion channels become activated very quickly after binding of ATP, methods with adequate time resolution have to be applied to investigate the early events induced by the agonist. Single-channel recordings were performed to describe conformational changes on P2X2, P2X4, and P2X7 receptors induced by ATP and also by allosteric receptor modifiers. The main results of these studies and the models of P2X receptor kinetics derived from these observations are reviewed here. The investigation of purinoceptors by means of the patch clamp technique following site-directed mutagenesis will probably reveal more details of P2X receptor function at the molecular level.

KeywordsKinetics Model P2X4 P2X7 Purinergic receptor Single channel Voltage clamp  Download fulltext PDF

Autor: Fritz Markwardt


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