Patient Preferences for Injectable Treatments for Multiple Sclerosis in the United States: A Discrete-Choice ExperimentReportar como inadecuado




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The Patient - Patient-Centered Outcomes Research

, Volume 9, Issue 2, pp 171–180

First Online: 11 August 2015DOI: 10.1007-s40271-015-0136-x

Cite this article as: Poulos, C., Kinter, E., Yang, JC. et al. Patient 2016 9: 171. doi:10.1007-s40271-015-0136-x

Abstract

Background and ObjectivePatients’ perceptions and experiences of medication efficacy, medication adverse events, dosing frequency, and dosing complexity have been found to influence adherence to injectable disease-modifying treatments DMTs in patients with multiple sclerosis MS. The aim of this study was to quantify patient preferences for features of injectable DMTs for MS.

MethodsAdult patients in the United States US with a self-reported diagnosis of MS completed an online discrete-choice experiment survey to assess preference for a number of features of a hypothetical injectable DMT. Patients chose hypothetical treatments in paired comparisons, where each treatment was described by features or attributes, including the number of years until disability progression, the number of relapses in the next 4 years, injection time, the frequency of injections, the occurrence of flu-like symptoms FLS, and severity of injection-site reactions. Random-parameters logit regression parameters were used to calculate preference weights of attribute levels and the relative importance of changes in treatment features.

ResultsOf the 205 patients who completed the survey, 192 provided sufficient data for analysis. The results indicated a broad range of tradeoffs that patients would be willing to make. With regard to this, the relative importance of an improvement in the number of years until disability progression from 1 to 2 i.e., vertical distance between preference weights for these attribute levels was 0.9 95 % confidence interval CI 0.5–1.2, the relative importance of this change was approximately equivalent to that of an improvement from 12 injections per month to two mean 0.8, 95 % CI 0.4–1.2, or approximately equivalent to a decrease from four to one relapses in the next 4 years mean 0.8, 95 % CI 0.5–1.2, or FLS 3 days after every injection to 3 days after some injections mean 1.0, 95 % CI 0.6–1.4.

ConclusionsThese results suggest that an improvement in treatment efficacy may be as important as a reduction in injection frequency or a reduction in some adverse events for patients who self-administer injectable DMTs for MS. Understanding the preferences of patients who use injectable treatments will inform the development of such treatments, which may in turn improve patient medication adherence and well-being.

Electronic supplementary materialThe online version of this article doi:10.1007-s40271-015-0136-x contains supplementary material, which is available to authorized users.

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Autor: Christine Poulos - Elizabeth Kinter - Jui-Chen Yang - John F. P. Bridges - Joshua Posner - Anthony T. Reder

Fuente: https://link.springer.com/







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