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Purinergic Signalling

, 3:39

First Online: 06 January 2007Received: 16 February 2006Accepted: 15 March 2006DOI: 10.1007-s11302-006-9035-x

Cite this article as: Guerra, A.N., Gavala, M.L., Chung, H.S. et al. Purinergic Signalling 2007 3: 39. doi:10.1007-s11302-006-9035-x


Elevated levels of extracellular nucleotides are present at sites of inflammation, platelet degranulation and cellular damage or lysis. These extracellular nucleotides can lead to the activation of purinergic nucleotide receptors on various leukocytes, including monocytes, macrophages, eosinophils, and neutrophils. In turn, nucleotide receptor activation has been linked to increased cellular production and release of multiple inflammatory mediators, including superoxide anion, nitric oxide and other reactive oxygen species ROS. In the present review, we will summarize the evidence that extracellular nucleotides can facilitate the generation of multiple ROS by leukocytes. In addition, we will discuss several potential mechanisms by which nucleotide-enhanced ROS production may occur. Delineation of these mechanisms is important for understanding the processes associated with nucleotide-induced antimicrobial activities, cell signalling, apoptosis, and pathology.

Key wordsextracellular nucleotides NADPH oxidases nitric oxide synthases purinergic receptors reactive oxygen species This work was supported by National Institutes of Health Grants HL56396 and AI50500.

The first author was supported by the Hematology Training Program NIH 5 T32 HL07899 at the University of Wisconsin.

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Autor: Alma N. Guerra - Monica L. Gavala - Hun Sun Chung - Paul J. Bertics


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