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Case Reports in Endocrinology - Volume 2016 2016, Article ID 4852907, 4 pages -

Case Report

University Hospital of Wales, Cardiff, UK

Department of Diabetes and Endocrinology, Royal Glamorgan Hospital, Mid Glamorgan CF72 8XR, UK

Royal Gwent Hospital, Newport, UK

Received 11 November 2015; Revised 21 December 2015; Accepted 22 December 2015

Academic Editor: Hidetoshi Ikeda

Copyright © 2016 Thomas Dacruz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 60-year old woman presented with features of Cushing’s syndrome CS secondary to an ectopic adrenocorticotropic hormone ACTH secreting metastatic parotid tumour 3 years after excision of the original tumour. She subsequently developed fatal intestinal perforation and unfortunately died despite best possible medical measures. Ectopic ACTH secretion accounts for 5–10% of all patients presenting with ACTH dependent hypercortisolism; small cell carcinoma of lung SCLC and neuroendocrine tumours NET account for the majority of such cases. Although there are 4 previous case reports of ectopic ACTH secreting salivary tumours in literature, to our knowledge this is the first published case report in which the CS developed after 3 years of what was deemed as a successful surgical excision of primary salivary tumour. Our patient initially had nonspecific symptoms which may have contributed to a delay in diagnosis. Perforation of sigmoid colon is a recognised though underdiagnosed complication associated with steroid therapy and hypercortisolism. This case demonstrates the challenges faced in diagnosis as well as management of patients with CS apart from the practical difficulties faced while trying to identify source of ectopic ACTH.





Autor: Thomas Dacruz, Atul Kalhan, Majid Rashid, and Kofi Obuobie

Fuente: https://www.hindawi.com/



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