Dahonggou Creek virus, a divergent lineage of hantavirus harbored by the long-tailed mole Scaptonyx fusicaudusReport as inadecuate

Dahonggou Creek virus, a divergent lineage of hantavirus harbored by the long-tailed mole Scaptonyx fusicaudus - Download this document for free, or read online. Document in PDF available to download.

Tropical Medicine and Health

, 44:16

First Online: 20 June 2016Received: 28 February 2016Accepted: 13 May 2016DOI: 10.1186-s41182-016-0017-6

Cite this article as: Kang, H., Gu, S., Cook, J.A. et al. Trop Med Health 2016 44: 16. doi:10.1186-s41182-016-0017-6


Novel hantaviruses, recently detected in moles order Eulipotyphla, family Talpidae from Europe, Asia, and North America would predict a broader host range and wider ecological diversity. Employing RT-PCR, archival frozen tissues from the Chinese shrew mole Uropsilus soricipes, broad-footed mole Scapanus latimanus, coast mole Scapanus orarius, Townsend’s mole Scapanus townsendii, and long-tailed mole Scaptonyx fusicaudus were analyzed for hantavirus RNA. Following multiple attempts, a previously unrecognized hantavirus, designated Dahonggou Creek virus DHCV, was detected in a long-tailed mole, captured in Shimian County, Sichuan Province, People’s Republic of China, in August 1989. Analyses of a 1058-nucleotide region of the RNA-dependent RNA polymerase-encoding L segment indicated that DHCV was genetically distinct from other rodent-, shrew-, mole-, and bat-borne hantaviruses. Phylogenetic trees, using maximum likelihood and Bayesian methods, showed that DHCV represented a divergent lineage comprising crocidurine and myosoricine shrew-borne hantaviruses. Although efforts to obtain the S- and M-genomic segments failed, the L-segment sequence analysis, reported here, expands the genetic database of non-rodent-borne hantaviruses. Also, by further mining natural history collections of archival specimens, the genetic diversity of hantaviruses will elucidate their evolutionary origins.

KeywordsHantavirus Talpid Evolution  Download fulltext PDF

Author: Hae Ji Kang - Se Hun Gu - Joseph A. Cook - Richard Yanagihara

Source: https://link.springer.com/

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