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Biological Procedures Online

, Volume 5, Issue 1, pp 211–221

Received: 06 August 2003Revised: 09 October 2003Accepted: 10 October 2003DOI: 10.1251-bpo64

Cite this article as: Yung, R.L., Ray, D., Mo, R.R. et al. Biol. Proced. Online 2003 5: 211. doi:10.1251-bpo64


Integrin adhesion molecules have important adhesion and signaling functions. They also play a central role in the pathogenesis of many autoimmune diseases. Over the past few years we have described a T cell adoptive transfer model to investigate the role of T cell integrin adhesion molecules in the development of autoimmunity. This report summarizes the methods we used in establishing this murine model. By treating murine CD4+ T cells with DNA hypomethylating agents and by transfection we were able to test thein vitro effects of integrin overexpression on T cell autoreactive proliferation, cytotoxicity, adhesion and trafficking. Furthermore, we showed that the ability to inducein vivo autoimmunity may be unique to the integrin lymphocyte function associated antigen-1 LFA-1.

Indexing termsIntegrins DNA methylation Published: October 24, 2003

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Autor: Raymond L. Yung - Donna Ray - Ru Ran Mo - Jun Chen

Fuente: https://link.springer.com/

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