Analysis of circulating insulin-like growth factor-1 IGF-1 and IGF binding protein-3 IGFBP-3 in tobacco smokers and non-smokersReport as inadecuate




Analysis of circulating insulin-like growth factor-1 IGF-1 and IGF binding protein-3 IGFBP-3 in tobacco smokers and non-smokers - Download this document for free, or read online. Document in PDF available to download.

Tobacco Induced Diseases

, 1:157

First Online: 15 June 2003Received: 02 July 2002Revised: 11 August 2002Accepted: 12 August 2002DOI: 10.1186-1617-9625-1-2-157

Cite this article as: Palmer, R., Wilson, R., Coward, P. et al. Tob. Induced Dis. 2003 1: 157. doi:10.1186-1617-9625-1-2-157

Abstract

BackgroundIGF-1 and the major serum IGF-1 binding protein, IGFBP-3, are under extensive investigation as potential prognostic markers of specific malignancies and vascular diseases. However, there is conflicting evidence that tobacco smoking may influence systemic concentrations of IGF-1 and IGFBP-3.

Subjects and methodsSerum concentrations of IGF-1 and IGFBP-3 were measured in 20 smokers and 20 non-smokers, matched for age and gender. Serum concentrations of cotinine, the major metabolite of nicotine, and ICAM-1, known to exhibit a dose-dependent relationship with cotinine, were also assayed.

ResultsThere was no difference between the systemic concentrations of IGF-1 or IGFBP-3 found in smokers and non-smokers IGF-1: mean s.d; 104 29 vs 101 24 ng ml, respectively; and IGFBP-3: 2562 522 vs 2447 570 ng ml, respectively. Similarly, there was no correlation between serum cotinine and IGF-1 or IGFBP-3 concentrations in smokers. Soluble ICAM-1 concentrations were significantly increased in smokers, compared to non-smokers mean s.d; 258 60 vs 194 50 ng ml, respectively; p = 0.002.

ConclusionThere was no relationship noted between tobacco smoking and either IGF-1 or IGFBP-3. These data suggest that smoking would not appear to be a major confounder of the reported clinical associations between IGF-1, IGFBP-3, or IGF-1-IGFBP-3 ratios and specific disease entities.

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Author: RM Palmer - RF Wilson - PY Coward - DA Scott

Source: https://link.springer.com/







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