Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and controlReport as inadecuate




Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control - Download this document for free, or read online. Document in PDF available to download.

Infectious Diseases of Poverty

, 5:71

First Online: 06 July 2016Received: 09 October 2015Accepted: 30 June 2016DOI: 10.1186-s40249-016-0166-1

Cite this article as: Tang, ZL., Huang, Y. & Yu, XB. Infect Dis Poverty 2016 5: 71. doi:10.1186-s40249-016-0166-1

Abstract

Clonorchiasis, caused by Clonorchis sinensis C. sinensis, is an important food-borne parasitic disease and one of the most common zoonoses. Currently, it is estimated that more than 200 million people are at risk of C. sinensis infection, and over 15 million are infected worldwide. C. sinensis infection is closely related to cholangiocarcinoma CCA, fibrosis and other human hepatobiliary diseases; thus, clonorchiasis is a serious public health problem in endemic areas. This article reviews the current knowledge regarding the epidemiology, disease burden and treatment of clonorchiasis as well as summarizes the techniques for detecting C. sinensis infection in humans and intermediate hosts and vaccine development against clonorchiasis. Newer data regarding the pathogenesis of clonorchiasis and the genome, transcriptome and secretome of C. sinensis are collected, thus providing perspectives for future studies. These advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis.

KeywordsClonorchiasis Clonorchis sinensis Diagnosis Pathogenesis Omics Prevention Electronic supplementary materialThe online version of this article doi:10.1186-s40249-016-0166-1 contains supplementary material, which is available to authorized users.

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Author: Ze-Li Tang - Yan Huang - Xin-Bing Yu

Source: https://link.springer.com/







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