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Infectious Diseases of Poverty

, 5:54

First Online: 07 July 2016Received: 05 February 2016Accepted: 18 May 2016DOI: 10.1186-s40249-016-0147-4

Cite this article as: Turner, H.C., Bettis, A.A., Chu, B.K. et al. Infect Dis Poverty 2016 5: 54. doi:10.1186-s40249-016-0147-4

Abstract

BackgroundLymphatic filariasis LF, also known as elephantiasis, is a neglected tropical disease NTD targeted for elimination through a Global Programme to Eliminate LF GPELF. Between 2000 and 2014, the GPELF has delivered 5.6 billion treatments to over 763 million people. Updating the estimated health and economic benefits of this significant achievement is important in justifying the resources and investment needed for eliminating LF.

MethodWe combined previously established models to estimate the number of clinical manifestations and disability-adjusted life years DALYs averted from three benefit cohorts those protected from acquiring infection, those with subclinical morbidity prevented from progressing and those with clinical disease alleviated. The economic savings associated with this disease prevention was then analysed in the context of prevented medical expenses incurred by LF clinical patients, potential income loss through lost-labour, and prevented costs to the health system to care for affected individuals. The indirect cost estimates were calculated using the human capital approach. A combination of four wage sources was used to estimate the fair market value of time for an agricultural worker with LF infection to ensure a conservative estimate, the lowest wage value was used.

ResultsWe projected that due to the first 15 years of the GPELF 36 million clinical cases and 175 116–250 million DALYs will potentially be averted. It was estimated that due to this notable health impact, US$100.5 billion will potentially be saved over the lifetimes of the benefit cohorts. This total amount results from summing the medical expenses incurred by LF patients US$3 billion, potential income loss US$94 billion, and costs to the health system US$3.5 billion that were projected to be prevented. The results were subjected to sensitivity analysis and were most sensitive to the assumed percentage of work hours lost for those suffering from chronic disease changing the total economic benefit between US$69.30–150.7 billion.

ConclusionsDespite the limitations of any such analysis, this study identifies substantial health and economic benefits that have resulted from the first 15 years of the GPELF, and it highlights the value and importance of continued investment in the GPELF.

KeywordsLymphatic filariasis DALYs averted Health impact Economic impact GPELF Programme evaluation Electronic supplementary materialThe online version of this article doi:10.1186-s40249-016-0147-4 contains supplementary material, which is available to authorized users.

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Autor: Hugo C. Turner - Alison A. Bettis - Brian K. Chu - Deborah A. McFarland - Pamela J. Hooper - Eric A. Ottesen - Mark H

Fuente: https://link.springer.com/







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