Clinical and demographic correlates of medication and visit adherence in a large randomized controlled trialReport as inadecuate

Clinical and demographic correlates of medication and visit adherence in a large randomized controlled trial - Download this document for free, or read online. Document in PDF available to download.

BMC Health Services Research

, 16:236

Healthcare needs and demand


BackgroundPatient characteristics are associated with adherence, which has implications for planning clinical research or designing payment systems that reward superior outcomes. It is unclear to what extent clinician efforts to improve adherence can attenuate these associations.

MethodsTo identify factors predicting visit and medication adherence in settings designed to optimize adherence, we did a retrospective analysis of participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial ALLHAT. ALLHAT recruited participants at 632 sites in North America, Puerto Rico, and the U.S. Virgin Islands for random assignment to antihypertensive treatment with amlodipine, chlorthalidone, or lisinopril. Site investigators reported clinic characteristics at the time they applied to participate in the study and research coordinators used standardized methods to measure patient characteristics. We defined adequate visit adherence as attending at least 80 % of scheduled visits; adequate medication adherence was defined as taking 80 % or more of the randomly assigned medication at all study visits.

ResultsThe 31,250 ALLHAT participants eligible for the visit adherence analysis attended 78.5 % of scheduled study visits; 68.9 % attended more than 80 % of scheduled visits. Clinic setting was predictive of both forms of adherence; adherence was worst at private clinics; clinics that enrolled more study participants had superior adherence. Adjusting for clinic characteristics and clinical factors, women, younger participants, Blacks and smokers were less likely to have adequate visit adherence. Among the 28,967 participants eligible for the medication adherence analysis, 21,261 73.4 % reported adequate medication adherence. In adjusted analyses, younger and less educated participants, Blacks, and smokers were less likely to report adequate adherence.

ConclusionsParticipant demographics were associated with adherence despite strenuous efforts to optimize adherence. Our results could inform decisions by researchers planning trials and policymakers designing payment systems.

Trial registrationNCT00000542. Registered 27 October 1999.

KeywordsAdherence Race Hypertension Hyperlipidemia Diuretics Angiotensin-converting enzyme inhibitors Calcium channel blockers Members of the ALLHAT Collaborative Research Group are listed in JAMA 2000;283:1973-1975

Electronic supplementary materialThe online version of this article doi:10.1186-s12913-016-1471-x contains supplementary material, which is available to authorized users.

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Author: Jeff Whittle - José-Miguel Yamal - Jeffrey D. Williamson - Charles E. Ford - Jeffrey L. Probstfield - Barbara L. Beard


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