The economic burden of asthma and chronic obstructive pulmonary disease and the impact of poor inhalation technique with commonly prescribed dry powder inhalers in three European countriesReport as inadecuate




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BMC Health Services Research

, 16:251

Utilization, expenditure, economics and financing systems

Abstract

BackgroundAsthma and chronic obstructive pulmonary disease COPD are common chronic inflammatory respiratory diseases, which impose a substantial burden on healthcare systems and society. Fixed-dose combinations FDCs of inhaled corticosteroids ICS and long-acting β2 agonists LABA, often administered using dry powder inhalers DPIs, are frequently prescribed to control persistent asthma and COPD. Use of DPIs has been associated with poor inhalation technique, which can lead to increased healthcare resource use and costs.

MethodsA model was developed to estimate the healthcare resource use and costs associated with asthma and COPD management in people using commonly prescribed DPIs budesonide + formoterol Turbuhaler or fluticasone + salmeterol Accuhaler over 1 year in Spain, Sweden and the United Kingdom UK. The model considered direct costs inhaler acquisition costs and scheduled and unscheduled healthcare costs, indirect costs productive days lost, and estimated the contribution of poor inhalation technique to the burden of illness.

ResultsThe direct cost burden of managing asthma and COPD for people using budesonide + formoterol Turbuhaler or fluticasone + salmeterol Accuhaler in 2015 was estimated at €813 million, €560 million, and €774 million for Spain, Sweden and the UK, respectively. Poor inhalation technique comprised 2.2–7.7 % of direct costs, totalling €105 million across the three countries. When lost productivity costs were included, total expenditure increased to €1.4 billion, €1.7 billion and €3.3 billion in Spain, Sweden and the UK, respectively, with €782 million attributable to poor inhalation technique across the three countries. Sensitivity analyses showed that the model results were most sensitive to changes in the proportion of patients prescribed ICS and LABA FDCs, and least sensitive to differences in the number of antimicrobials and oral corticosteroids prescribed.

ConclusionsThe cost of managing asthma and COPD using commonly prescribed DPIs is considerable. A substantial, and avoidable, contributor to this burden is poor inhalation technique. Measures that can improve inhalation technique with current DPIs, such as easier-to-use inhalers or better patient training, could offer benefits to patients and healthcare providers through improving disease outcomes and lowering costs.

KeywordsAsthma Burden of illness COPD Cost DPI Model Poor inhalation technique Electronic supplementary materialThe online version of this article doi:10.1186-s12913-016-1482-7 contains supplementary material, which is available to authorized users.

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Author: A. Lewis - S. Torvinen - P. N. R. Dekhuijzen - H. Chrystyn - A. T. Watson - M. Blackney - A. Plich

Source: https://link.springer.com/







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