Synthesis by high-efficiency liquid-phase HELP method of oligonucleotides conjugated with high-molecular weight polyethylene glycols PEGsReport as inadecuate




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Biological Procedures Online

, Volume 1, Issue 1, pp 59–69

DOI: 10.1251-bpo2

Cite this article as: Bonora, G.M., Zaramella, S. & Veronese, F.M. Biol Proced Online 1998 1: 59. doi:10.1251-bpo2

Abstract

The chemical modification of synthetic oligonucleotides has recently been investigated to improve their pharmacological utilization. In addition to chemical alterations of the backbone and of the heterocyclic bases, their conjugation with amphiphylic moieties, such as the polyethylene glycol has been proposed. The large scale production of these molecules as demanded for commercial purposes is hampered by the heterogeneity of the solid-phase processes and by the low reactivity of high-molecular weight PEGs in solution. A new synthetic procedure based on the recently developed liquid-phase method HELP, has been set up to overcome these limitations.

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Author: G. M. Bonora - S. Zaramella - F. M. Veronese

Source: https://link.springer.com/







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