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BioMed Research InternationalVolume 2014 2014, Article ID 426028, 19 pages

Review Article

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

Department of Materials Science & Engineering, University of Washington, Seattle, WA 98125, USA

Received 2 November 2013; Accepted 7 January 2014; Published 20 May 2014

Academic Editor: Sung Jean Park

Copyright © 2014 Qing Jiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nanoparticles NPs have promising applications in medicine. Immune system is an important protective system to defend organisms from non-self matters. NPs interact with the immune system and modulate its function, leading to immunosuppression or immunostimulation. These modulating effects may bring benefits or danger. Compositions, sizes, and surface chemistry, and so forth, affect these immunomodulations. Here we give an overview of the relationship between the physicochemical properties of NPs, which are candidates to be applied in medicine, and their immunomodulation properties.

Autor: Qing Jiao, Liwen Li, Qingxin Mu, and Qiu Zhang



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