Microarray Analysis of the Juvenile Hormone Response in Larval Integument of the Silkworm, Bombyx moriReportar como inadecuado

Microarray Analysis of the Juvenile Hormone Response in Larval Integument of the Silkworm, Bombyx mori - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

International Journal of Genomics - Volume 2014 2014, Article ID 426025, 15 pages -

Research Article

State Key Laboratory of Silkworm Genome Biology, Southwest University, No. 2, Tiansheng Road, Beibei District, Chongqing 400715, China

School of Life Science, Southwest University, Chongqing 400715, China

Received 22 November 2013; Revised 29 January 2014; Accepted 20 February 2014; Published 6 April 2014

Academic Editor: Prabhakara V. Choudary

Copyright © 2014 Daojun Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Juvenile hormone JH coordinates with 20-hydroxyecdysone 20E to regulate larval growth and molting in insects. However, little is known about how this cooperative control is achieved during larval stages. Here, we induced silkworm superlarvae by applying the JH analogue JHA methoprene and used a microarray approach to survey the mRNA expression changes in response to JHA in the silkworm integument. We found that JHA application significantly increased the expression levels of most genes involved in basic metabolic processes and protein processing and decreased the expression of genes associated with oxidative phosphorylation in the integument. Several key genes involved in the pathways of insulin-insulin-like growth factor signaling IIS and 20E signaling were also upregulated after JHA application. Taken together, we suggest that JH may mediate the nutrient-dependent IIS pathway by regulating various metabolic pathways and further modulate 20E signaling.

Autor: Daojun Cheng, Jian Peng, Meng Meng, Ling Wei, Lixia Kang, Wenliang Qian, and Qingyou Xia

Fuente: https://www.hindawi.com/


Documentos relacionados