Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with Infective Endocarditis and Chronic Hepatitis CReportar como inadecuado




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Canadian Journal of Infectious Diseases and Medical Microbiology - Volume 2016 2016, Article ID 3585860, 6 pages -

Case Report

Department of Medicine, University of Calgary, Calgary, AB, Canada T2N 4N1

Department of Medicine, Division of General Internal Medicine, University of Calgary, Calgary, AB, Canada T2N 4N1

Received 10 June 2015; Accepted 21 December 2015

Copyright © 2016 Fareed B. Kamar and T. Lee-Ann Hawkins. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

While antineutrophil cytoplasmic antibody ANCA is often used as a diagnostic marker for certain vasculitides, ANCA induction in the setting of infection is much less common. In the case of infective endocarditis, patients may present with multisystem disturbances resembling an autoimmune process, cases that may be rendered even trickier to diagnose in the face of a positive ANCA. Though not always straightforward, distinguishing an infective from an inflammatory process is pivotal in order to guide appropriate therapy. We describe an encounter with a 43-year-old male with chronically untreated hepatitis C virus infection who featured ANCA positivity while hospitalized with acute bacterial endocarditis. His case serves as a reminder of two of the few infections known to uncommonly generate ANCA positivity. We also summarize previously reported cases of ANCA positivity in the context of endocarditis and hepatitis C infections.





Autor: Fareed B. Kamar and T. Lee-Ann Hawkins

Fuente: https://www.hindawi.com/



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