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Tropical Medicine and Health

, 44:33

First Online: 27 September 2016Received: 11 May 2016Accepted: 14 September 2016DOI: 10.1186-s41182-016-0033-6

Cite this article as: Wah, S.T., Hananantachai, H., Kerdpin, U. et al. Trop Med Health 2016 44: 33. doi:10.1186-s41182-016-0033-6


Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.

KeywordsCerebral malaria Genetics Pathogenesis MicroRNA AbbreviationsATSAcidic terminal sequence

CIDRCysteine-rich interdomain region

CMCerebral malaria

CspCircumsporozoite protein

DBLDuffy binding-like


ICAM-1Intercellular adhesion molecule-1


KAHRPKnob-associated histidine-rich protein

memTNFTransmembrane form of TNF


Msp-1Merozoite surface protein 1

Msp-2Merozoite surface protein 2

NTSN-terminal sequence

PbAP. berghei ANKA

PfEMP1P. falciparum erythrocyte membrane protein 1

pRBCsParasitized red blood cells

SNPsSingle nucleotide polymorphisms

TNFR2Tissue necrotic factor receptor 2

TNF-αTumor necrosis factor alpha

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Autor: Saw Thu Wah - Hathairad Hananantachai - Usanee Kerdpin - Chotiros Plabplueng - Virapong Prachayasittikul - Pornlada Nuchnoi


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