EuroQol Protocols for Time Trade-Off Valuation of Health OutcomesReport as inadecuate

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, Volume 34, Issue 10, pp 993–1004

First Online: 15 April 2016DOI: 10.1007-s40273-016-0404-1

Cite this article as: Oppe, M., Rand-Hendriksen, K., Shah, K. et al. PharmacoEconomics 2016 34: 993. doi:10.1007-s40273-016-0404-1


The time trade-off TTO valuation technique is widely used to determine utility values of health outcomes to inform quality-adjusted life-year QALY calculations for use in economic evaluation. Protocols for implementing TTO vary in aspects such as the trade-off framework, iteration procedure and its administration model and method, training of respondents and interviewers, and quality control of data collection. The most widely studied and utilized TTO valuation protocols are the Measurement and Valuation of Health MVH protocol, the Paris protocol and the EuroQol Valuation Technology EQ-VT protocol, all developed by members of the EuroQol Group. The MVH protocol and its successor, the Paris protocol, were developed for valuation of EQ-5D-3L health states. Both protocols were designed for a trained interviewer to elicit preferences from a respondent using the conventional TTO framework with a fixed time horizon of 10 years and an iteration procedure combining bisection and titration. Developed for valuation of EQ-5D-5L health states, the EQ-VT protocol adopted a composite TTO framework and made use of computer technology to facilitate data collection. Training and monitoring of interviewers and respondents is a pivotal component of the EQ-VT protocol. Research is underway aiming to further improve the EuroQol protocols, which form an important basis for the current practice of health technology assessment in many countries.

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Author: Mark Oppe - Kim Rand-Hendriksen - Koonal Shah - Juan M. Ramos‐Goñi - Nan Luo


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