Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene PolymorphismsReportar como inadecuado




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BioMed Research International - Volume 2016 2016, Article ID 3567527, 5 pages -

Research Article

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 1 Chalubinskiego Street, 50-368 Wroclaw, Poland

Department of Endocrinology and Diabetology, Wroclaw Medical University, 4 Pasteura Street, 50-367 Wroclaw, Poland

Department of Health Promotion, University School of Physical Education, 35 Paderewskiego Street, 51-612 Wroclaw, Poland

Received 21 December 2015; Revised 24 January 2016; Accepted 1 February 2016

Academic Editor: Daniela Parolaro

Copyright © 2016 Monika Heisig et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Uremic pruritus UP is a frequent and bothersome symptom in hemodialysis patients. Its etiology is not fully understood and that is why there is no specific treatment. The endocannabinoid system plays a role in many pathological conditions. There is reliable evidence on the association between cannabinoid system and pruritus. In our study, we aimed to evaluate whether genetic variations in the endocannabinoid receptor 1 CNR1 gene can affect UP. The rs12720071, rs806368, rs1049353, rs806381, rs10485170, rs6454674, and rs2023239 polymorphisms of the CNR1 gene were genotyped in 159 hemodialysis patients and 150 healthy controls using two multiplex polymerase chain reactions and the minisequencing technique. No statistically significant relationship was found in any of the evaluated genotypes between patients with and without UP, even after excluding patients with diabetes and dyslipidemia. There were no differences between patients with UP and the control group. However, in the group of all HD patients, a significantly higher incidence of GA genotype and lower incidence in GG genotype in the polymorphism rs806381s were revealed versus the control group . It seems that polymorphisms of the CNR1 gene are not associated with uremic pruritus.





Autor: Monika Heisig, Łukasz Łaczmański, Adam Reich, Felicja Lwow, and Jacek C. Szepietowski

Fuente: https://www.hindawi.com/



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