Antioxidative Role of Hatikana Leea macrophylla Roxb. Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino RatsReportar como inadecuado




Antioxidative Role of Hatikana Leea macrophylla Roxb. Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BioMed Research International - Volume 2015 2015, Article ID 356729, 12 pages -

Research ArticleDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh

Received 5 April 2015; Revised 22 May 2015; Accepted 24 May 2015

Academic Editor: Kazim Husain

Copyright © 2015 Samina Akhter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla Roxb. crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as normal control, hepatic control, and reference control silymarin group and treatment group. Evaluations were made for the effects of the fractions on serum enzymes and biochemical parameters of CCl4-induced albino rat. Histopathological screening was also performed to evaluate the changes of liver tissue before and after treatment. Different fractions of Leea macrophylla showed very potent 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging effect, FeCl3 reducing effect, superoxide scavenging effect, and iron chelating effect. Carbon tetrachloride induction increased the level of serum aspartate aminotransferase AST, alanine aminotransferase ALT, and alkaline phosphatase ALP and other biochemical parameters such as lipid profiles, total protein, and CK-MB. In contrast, treatment of Leea macrophylla reduced the serum aspartate aminotransferase AST, alanine aminotransferase ALT, and alkaline phosphatase ALP activities as well as biochemical parameters activities. L. macrophylla partially restored the lipid profiles, total protein, and CK-MB. Histopathology showed the treated liver towards restoration. Results evidenced that L. macrophylla can be prospective source of hepatic management in liver injury.





Autor: Samina Akhter, Md. Atiar Rahman, Jannatul Aklima, Md. Rakibul Hasan, and J. M. Kamirul Hasan Chowdhury

Fuente: https://www.hindawi.com/



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