Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular FibrillationReportar como inadecuado




Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BioMed Research International - Volume 2016 2016, Article ID 3567275, 13 pages -

Research Article

Department of Anaesthetics, Liver Transplant Unit, King’s College Hospital, London, UK

Neonatology Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

Department of Biopathology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

MSc -Cardiopulmonary Resuscitation-, Medical School, National and Kapodistrian University of Athens, Athens, Greece

ELPEN Research-Experimental Centre, Athens, Greece

2nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece

Division of Pathology, Department of Surgical Sciences, University of Cagliari Medical School, Cagliari, Italy

School of Medicine, European University Cyprus, Nicosia, Cyprus

Received 19 July 2016; Revised 13 September 2016; Accepted 21 September 2016

Academic Editor: Hideo Inaba

Copyright © 2016 Charalampos Pantazopoulos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace-Large-White piglets aged 10–15 weeks with average weight of  kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group Group C received saline as placebo, whereas the EPO group Group E received EPO 5000 U-kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation. Results. Five animals 41.67% from Group C and 11 animals 91.67% from Group E achieved ROSC . Eight animals 66.67%, 5 surviving and 3 nonsurviving from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI . There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 summed mean values’ , 0.01, and 0.004, resp

Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury.





Autor: Charalampos Pantazopoulos, Nicoletta Iacovidou, Evangelia Kouskouni, Paraskevi Pliatsika, Apostolos Papalois, Georgios Kaparo

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados