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Evidence-Based Complementary and Alternative MedicineVolume 2013 2013, Article ID 356705, 7 pages

Research Article

Department of Pediatrics, Chi-Mei Medical Center, Yong Kang, Tainan City 73101, Taiwan

The Center of General Education, Chia Nan University of Pharmacy & Science, Rende, Tainan City 71710, Taiwan

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan

Graduate Institute of Medical Sciences, Chang Jung Christian University, Quei-Jen, Tainan City 71101, Taiwan

Department of Medical Research, Chi-Mei Medical Center, Yong Kang, Tainan City 73101, Taiwan

Received 4 February 2013; Revised 18 March 2013; Accepted 30 March 2013

Academic Editor: Francis B. Lewu

Copyright © 2013 Lin-Yu Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hibiscus taiwanensis Malvaceae is widely used as an alternative herb to treat disorders in Taiwan. In the present study, it is used to screen the effect on diabetic hyperglycemia in streptozotocin-induced diabetic rats STZ-diabetic rats. The extract of Hibiscus taiwanensis showed a significant plasma glucose-lowering action in STZ-diabetic rats. Stems of Hibiscus taiwanensis are more effective than other parts to decrease the plasma glucose in a dose-dependent manner. Oral administration of Hibiscus taiwanensis three times daily for 3 days into STZ-diabetic rats increased the sensitivity to exogenous insulin showing an increase in insulin sensitivity. Moreover, similar repeated administration of Hibiscus taiwanensis for 3 days in STZ-diabetic rats produced a marked reduction of phosphoenolpyruvate carboxykinase PEPCK expression in liver and an increased expression of glucose transporter subtype 4 GLUT 4 in skeletal muscle. Taken together, our results suggest that Hibiscus taiwanensis has the ability to lower plasma glucose through an increase in glucose utilization via elevation of skeletal GLUT 4 and decrease of hepatic PEPCK in STZ-diabetic rats.

Autor: Lin-Yu Wang, Hsien-Hui Chung, and Juei-Tang Cheng



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