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Oxidative Medicine and Cellular Longevity - Volume 2016 2016, Article ID 3565127, 18 pages -

Review Article

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy

Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK

University-BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16-4TJ, UK

Istituto Nazionale di Biostrutture e Biosistemi, 00136 Roma, Italy

Received 16 December 2015; Revised 2 April 2016; Accepted 6 April 2016

Academic Editor: Michael Courtney

Copyright © 2016 Pierpaola Davalli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aging process worsens the human body functions at multiple levels, thus causing its gradual decrease to resist stress, damage, and disease. Besides changes in gene expression and metabolic control, the aging rate has been associated with the production of high levels of Reactive Oxygen Species ROS and-or Reactive Nitrosative Species RNS. Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process. Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. Therapeutic interventions towards senescent cells might allow restoring the health and curing the diseases that share basal processes, rather than curing each disease in separate and symptomatic way. Here, we review observations on ROS ability of inducing cell senescence through novel mechanisms that underpin aging processes. Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging.

Autor: Pierpaola Davalli, Tijana Mitic, Andrea Caporali, Angela Lauriola, and Domenico D’Arca



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