Guilty Molecules, Guilty Minds The Conflicting Roles of the Innate Immune Response to Traumatic Brain InjuryReport as inadecuate




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Mediators of InflammationVolume 2012 2012, Article ID 356494, 18 pages

Review Article

National Trauma Research Institute, The Alfred Hospital, 89 Commercial Road, Melbourne, VIC 3004, Australia

Department of Medicine, Monash University, Melbourne, VIC 3004, Australia

Department of Surgery, Monash University, Melbourne, VIC 3004, Australia

Received 22 December 2011; Accepted 26 March 2012

Academic Editor: Mohamed Lamkanfi

Copyright © 2012 Sarah Claire Hellewell and Maria Cristina Morganti-Kossmann. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Traumatic brain injury TBI is a complex disease in the most complex organ of the body, whose victims endure lifelong debilitating physical, emotional, and psychosocial consequences. Despite advances in clinical care, there is no effective neuroprotective therapy for TBI, with almost every compound showing promise experimentally having disappointing results in the clinic. The complex and highly interrelated innate immune responses govern both the beneficial and deleterious molecular consequences of TBI and are present as an attractive therapeutic target. This paper discusses the positive, negative, and often conflicting roles of the innate immune response to TBI in both an experimental and clinical settings and highlights recent advances in the search for therapeutic candidates for the treatment of TBI.





Author: Sarah Claire Hellewell and Maria Cristina Morganti-Kossmann

Source: https://www.hindawi.com/



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