Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South IndiaReport as inadecuate




Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South India - Download this document for free, or read online. Document in PDF available to download.

Advances in Medicine - Volume 2016 2016, Article ID 3564359, 6 pages -

Research Article

Department of Microbiology, Government Medical College Kozhikode, Kozhikode 673016, India

Department of Infectious Diseases, Government Medical College Kozhikode, Kozhikode 673016, India

Received 11 April 2016; Accepted 21 June 2016

Academic Editor: Lucia Lopalco

Copyright © 2016 Vishnu Kaniyarakkal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acquired immunodeficiency syndrome and related opportunistic infections are a significant cause of morbidity and mortality in susceptible population. This study aims to negate the paucity of data regarding the relation between CD4 levels, prevalence of enteric parasites, and the outcome of treatment with HAART highly active antiretroviral therapy and Cotrimoxazole in Kerala, India. Multiple stool samples from 200 patients in a cross-sectional study were subjected to microscopy and Cryptosporidium stool antigen ELISA. Parasites were identified in 18 samples 9%. Cystoisospora and Cryptosporidium spp. were seen in 9 cases 4.5% and 5 cases 2.5%, respectively. Microsporidium spores and Chilomastix mesnili cysts were identified in 1 case each 0.5% each. Seven cases of Cystoisospora diarrhoea recovered after treatment with Cotrimoxazole. Diarrhoea due to Cryptosporidium spp. in all 5 cases subsided after immune reconstitution with HAART. This study concludes that a positive association was seen between low CD4 count <200 cells-μL and overall parasite positivity value < 0.01. ELISA is a more sensitive modality for the diagnosis of Cryptosporidium diarrhoea. Chilomastix mesnili, generally considered a nonpathogen, may be a cause of diarrhoeal disease in AIDS. Immune reconstitution and Cotrimoxazole prophylaxis remain to be the best therapeutic approach in AIDS-related diarrhoea.





Author: Vishnu Kaniyarakkal, Nizamuddin Mundangalam, Anitha Puduvail Moorkoth, and Sheela Mathew

Source: https://www.hindawi.com/



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