Single-Blind, Prospective, Randomized Study of Cefmetazole and Cefoxitin in the Treatment of Postcesarean EndometritisReportar como inadecuado




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Infectious Diseases in Obstetrics and Gynecology - Volume 3 1995, Issue 1, Pages 28-33

Clinical Study

Department of Ob-Gyn-REI, Temple University Hospital, 3401 N. Broad Street, Philadelphia 19140, PA, USA

University of Texas Medical Branch at Galveston, TX, USA

University of California, San Francisco General Hospital, San Francisco, CA, USA

University of New Mexico School of Medicine, Albuquerque, NM, USA

Upjohn Company, Kalamazoo, MI, USA

Received 28 September 1994; Accepted 14 February 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: The purpose of this study was to compare the clinical efficacy and safety of cefmetazolegiven by IV push with that of parenterally administered cefoxitin for the treatment of endometritis following cesarean delivery.

Methods: In a single-blind, multicenter, prospective, randomized study, 355 patients with endometritis after cesarean delivery were enrolled and received medication. Administered was either cefmetazole sodium, 2 g by IV push over 1 min q 8 h, or cefoxitin sodium, 2 g IV q 6 h in a 2:1 ratio. The patients were followed for clinical responses and side effects.

Results: The cure rate for cefmetazole was 89% and for cefoxitin it was 79% P = 0.006. The adverse events were similar in both groups.

Conclusions: Cefmetazole was significantly more effective than cefoxitin in the treatment of endometritis following cesarean delivery.





Autor: Ashwin Chatwani, Mark Martens, David A. Grimes, Molly Chatterjee, Melvin Noah, Marion M. Stamp-Cole, Kimberly T. Perry, and the C

Fuente: https://www.hindawi.com/



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