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Environmental Health

, 15:97

First Online: 12 October 2016Received: 21 May 2016Accepted: 28 September 2016DOI: 10.1186-s12940-016-0180-6

Cite this article as: Mandrioli, D., Belpoggi, F., Silbergeld, E.K. et al. Environ Health 2016 15: 97. doi:10.1186-s12940-016-0180-6

Abstract

Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1 the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2 techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3 the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.

KeywordsAneuploidy Carcinogens Reproductive toxicants Endocrine disruptors Chromosomes Early diagnose Bioassays Risk assessment mFISH Laser scanning microscopy AbbreviationsCatsperCation channels of sperm

DNADeoxyribonucleic acid

FISHFluorescence in situ hybridization

GSHGenome in situ hybridization

IHCImmunohistochemistry

p,p’-DDEDichlorodiphenyldichloroethylene

PAP-testPapanicolaou test

PCRPolymerase chain reaction

RNARibonucleic acid

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Autor: Daniele Mandrioli - Fiorella Belpoggi - Ellen K. Silbergeld - Melissa J. Perry

Fuente: https://link.springer.com/







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