#Nitrosocarbonyls 1: Antiviral Activity of N-4-Hydroxycyclohex-2-en-1-ylquinoline-2-carboxamide against the Influenza A Virus H1N1Report as inadecuate




#Nitrosocarbonyls 1: Antiviral Activity of N-4-Hydroxycyclohex-2-en-1-ylquinoline-2-carboxamide against the Influenza A Virus H1N1 - Download this document for free, or read online. Document in PDF available to download.

The Scientific World Journal - Volume 2014 2014, Article ID 472373, 10 pages -

Research ArticleDepartment of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy

Received 2 November 2014; Accepted 5 December 2014; Published 31 December 2014

Academic Editor: Georgiy B. Shul’pin

Copyright © 2014 Dalya Al-Saad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1.

“Dedicated to the CINMPIS on the occasion of its 20th anniversary”





Author: Dalya Al-Saad, Misal Giuseppe Memeo, and Paolo Quadrelli

Source: https://www.hindawi.com/



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