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Annals of Occupational and Environmental Medicine

, 28:66

First Online: 18 November 2016Received: 07 April 2016Accepted: 07 September 2016DOI: 10.1186-s40557-016-0137-9

Cite this article as: Han, S., Hwang, I., Kim, S.M. et al. Ann of Occup and Environ Med 2016 28: 66. doi:10.1186-s40557-016-0137-9

Abstract

BackgroundAgent Orange AO is the code name for one of the herbicides and defoliants used in the Vietnam War. Studies conducted thus far show a significant correlation between AO and the occurrence of cardiovascular diseases. But there is little data on the association between AO and stroke, and limited studies have targeted patient groups exposed to AO.

MethodBohun medical center Institutional Review Board IRB approved the study. ID: 341 We studied patients with acute ischemic stroke within 7 days of onset in VHS medical center and 4 other general hospitals. Among them, 91 consecutive patients with previous exposure to AO were evaluated. For controlled group, 288 patients with no history of AO exposure were chosen.

ResultThere were 49 44.0 % DM patient with a higher frequency in the exposure group 93 32.3 % in control P = 0.045. There were 6 6.6 % hyperlipidemia in exposure group and 69 24.0 % in control. P < 0.002. Small vessel occlusion was the most common subtype 36, 39.6 % in exposure group but in control group, the large artery atherosclesosis was 120, 41.7 % P = 0.014.

The NIHSS of the exposure group on admission showed lower scores median values, 2 and 4, respectively; P = 0.003. The median mRS was 1 for the exposure group and 2 for the control group, at discharge and after 3 months. After 3 months of discharge, 55 60.4 % in the exposure group and 171 59.4 % in the control group showed below mRS 1 P = 0.001.

ConclusionThis study targeted patients who are Vietnam veteran. There is some difference in vascular risk factors and clinical manifestations suggest AO exposure has contributed to a certain extent to the stroke.

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Autor: SangWoo Han - Inha Hwang - Seung Min Kim - Young Soon Yang - SangWon Ha - Jeong Ho Han - Tae Hwan Park

Fuente: https://link.springer.com/







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