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ISRN AllergyVolume 2011 2011, Article ID 426941, 4 pages

Research Article

Department of Paediatrics, University of Otago, Wellington 6242, New Zealand

Wellington Asthma Research Group, University of Otago, Wellington 6242, New Zealand

Department of Medicine, University of Otago, Wellington School of Medicine and Health Sciences, P.O. Box 7343, Wellington South 6242, New Zealand

Received 16 November 2011; Accepted 20 December 2011

Academic Editor: H. Brok

Copyright © 2011 Claire Smith et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bedding dust is a mixture of many components, of which the house dust mite HDM allergen, Der p 1, is the most allergenic. There has been little work to investigate the effect of other bedding dust components on HDM sensitisation. The objective of the study was to determine the effect of endotoxin in bedding dust on the allergic response in HDM-sensitised individuals. Twenty-nine house dust mite-sensitised adults were skin prick and allergen patch tested against a sterile solution of their own bedding dust and against a solution containing the same concentration of Der p 1 as the bedding solution for comparison. There was no significant difference in wheal size between the diluted house dust mite solution and the bedding dust in spite of their high levels of endotoxin. Symptomatic subjects had larger, but not statistically significant, responses to commercial house dust mite solution than asymptomatic subjects. Allergen patch test responses were negative in 22-29 of subjects using either bedding dust solutions or comparable diluted house dust mite solutions. An individual-s own bedding dust does not appear to contain factors that enhance skin prick test or atopy patch test responses to house dust mites.

Autor: Claire Smith, Thorsten Stanley, Julian Crane, and Robert Siebers



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