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Infectious Diseases of Poverty

, 6:4

First Online: 10 January 2017Received: 05 January 2016Accepted: 15 December 2016DOI: 10.1186-s40249-016-0222-x

Cite this article as: Huang, YM., Shi, LW., She, R. et al. Infect Dis Poverty 2017 6: 4. doi:10.1186-s40249-016-0222-x


BackgroundThough many countries, including China, are moving towards malaria elimination, malaria remains a major global health threat. Due to the spread of antimalarial drug resistance and the need for innovative medical products during the elimination phase, further research and development RandD of innovative tools in both epidemic and elimination areas is needed. This study aims to identify the trends and gaps in malaria RandD in China, and aims to offer suggestions on how China can be more effectively involved in global malaria RandD.

MethodsQuantitative analysis was carried out by collecting data on Chinese malaria-related research programmes between 1985 and 2014, invention patents in China from 1985 to 2014, and articles published by Chinese researchers in PubMed and Chinese databases from 2005 to 2014. All data were screened and extracted for numerical analysis and were categorized into basic sciences, drug-drug resistance, immunology-vaccines, or diagnostics-detection for chronological and subgroup comparisons.

ResultsThe number of malaria RandD activities have shown a trend of increase during the past 30 years, however these activities have fluctuated within the past few years. During the past 10 years, RandD on drug-drug resistance accounted for the highest percentages of research programmes 32.4%, articles 55.0% in PubMed and 50.6% in Chinese databases and patents 45.5%. However, these RandD activities were mainly related to artemisinin. RandD on immunology-vaccines has been a continuous interest for China’s public entities, but the focus remains on basic science. RandD in the area of high-efficiency diagnostics has been rarely seen or reported in China.

ConclusionsChina has long been devoted to malaria RandD in multiple areas, including drugs, drug resistance, immunology and vaccines. RandD on diagnostics has received significantly less attention, however, it should also be an area where China can make a contribution. More focus on malaria RandD is needed, especially in the area of diagnostics, if China would like to contribute in a more significant way to global malaria control and elimination.

KeywordsResearch and development RandD Malaria Antimalarial China AbbreviationsACTsArtemisinin combination therapies

CEWGConsultative Expert Working Group

CNKIChina National Knowledge Infrastructure

G6PDGlucose-6-phosphate dehydrogenase

LAMPLoop-mediated isothermal amplification

M.RCAg-1Malaria Random Constructed Antigen-1

RandDResearch and development

RDTsRapid diagnostic tests

TBVTransmission blocking vaccine

WHOWorld Health Organization

Electronic supplementary materialThe online version of this article doi:10.1186-s40249-016-0222-x contains supplementary material, which is available to authorized users.

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Autor: Yang-Mu Huang - Lu-Wen Shi - Rui She - Jing Bai - Shi-Yong Jiao - Yan Guo


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