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Malaria Journal

, 16:103

First Online: 04 March 2017Received: 19 October 2016Accepted: 28 February 2017DOI: 10.1186-s12936-017-1757-4

Cite this article as: Wilmot, D., Ameyaw, E.O., Amoako-Sakyi, D. et al. Malar J 2017 16: 103. doi:10.1186-s12936-017-1757-4

Abstract

BackgroundAnti-malarial herbal preparations HPs continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy ACT, the recommended first choice for treatment of uncomplicated malaria in the country, remains efficacious. A major issue with the use of these preparations is inadequate or unreliable data on their efficacy and quality. An assessment of the potency and quality of the most popular commercial anti-malarial HPs in Ghana was, therefore, carried out. The outcome of this investigation is herein discussed preceded by a short literature review of herbal medicines in Ghana.

MethodsUsing a questionnaire survey of 344 individuals in parts of Ghana, five of the most frequently used HPs were identified and selected for test of their efficacy and quality. The effect of the selected compounds on Plasmodium berghei in vivo was assessed using standard methods.

ResultsAll five tested HPs HP-A, HP-B, HP-C, HP-D and HP-E showed chemo-suppressive activity against P. berghei in vivo. However the degree of parasites inhibition is significantly lower compared to the WHO-recommended artemether–lumefantrine combination p < 0.05, 99.9% chemosuppression-activity, 28 days survival. Using the Solomon Saker’s Test, two of the preparations were found to contain chloroquine or compounds with chemical properties like that of chloroquine.

ConclusionPopular anti-malarial HPs used in southern Ghana were found to have chemo-suppressive properties. Intentional addition of chloroquine or SCs to these preparations in order to enhance their effectiveness has serious public health concerns as it may induce cross resistance to amodiaquine, one of the partner drugs in the recommended ACT for use in Ghana.

KeywordsAnti-malarial drug Plasmodium falciparum ICR mice Plasmodium berghei Chemosuppression Herbal-preparations In vivo AbbreviationsACTartemisinin combination therapy

A-Lartesunate+lumefantrine

CQchloroquine

HPherbal preparation

HP-Aherbal preparation coded -A-

HP-Bherbal preparation coded -B-

HP-Cherbal preparation coded -C-

HP-Dherbal preparation coded -D-

HP-Eherbal preparation coded -E-

HPsherbal preparations

ICR miceimprinting control region mice

SEMstandard error of mean

SCsimilar compound

WHOWorld Health Organization

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Autor: Dennis Wilmot - Elvis Ofori Ameyaw - Daniel Amoako-Sakyi - Johnson Nyarko Boampong - Neils Ben Quashie

Fuente: https://link.springer.com/







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