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Stem Cells InternationalVolume 2012 2012, Article ID 184154, 10 pages

Review Article

Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, 70013 Crete, Greece

Department of Biology, University of Crete, Heraklion, 71409 Crete, Greece

Received 12 October 2011; Accepted 19 December 2011

Academic Editor: Andras Dinnyes

Copyright © 2012 Androniki Kretsovali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Histone deacetylase inhibitors HDACi are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages. They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies.

Autor: Androniki Kretsovali, Christiana Hadjimichael, and Nikolaos Charmpilas

Fuente: https://www.hindawi.com/


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