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Journal of Biomedical Science

, 18:23

First Online: 22 March 2011Received: 03 March 2011Accepted: 22 March 2011DOI: 10.1186-1423-0127-18-23

Cite this article as: Kaberdin, V.R., Singh, D. & Lin-Chao, S. J Biomed Sci 2011 18: 23. doi:10.1186-1423-0127-18-23


RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in Escherichia coli and discuss their conservation in evolutionarily distant bacteria.

Electronic supplementary materialThe online version of this article doi:10.1186-1423-0127-18-23 contains supplementary material, which is available to authorized users.

Vladimir R Kaberdin, Dharam Singh contributed equally to this work.

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Autor: Vladimir R Kaberdin - Dharam Singh - Sue Lin-Chao


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