Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertensionReport as inadecuate




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Oxidative stress has been associated with mechanisms of EH essential hypertension. The aim ofthe present study was to test the hypothesis that the antioxidant properties of vitamins C and Eare associated with a decrease in BP blood pressure in patients with EH. A randomized doubleblindplacebo-controlled clinical trial was conducted in 110 men with grade 1 EH 35–60 years ofage without obesity, dyslipidaemia and diabetes mellitus, non-smokers, not undergoing vigorousphysical exercise, without the use of any medication and-or high consumption of fruit and vegetables.Participants were randomly assigned to receive either vitamins C+E vitamin C 1 g-dayplus vitamin E 400 international units-day or placebo for 8 weeks. Measurements included24 h ambulatory BP and blood analysis of oxidative-stress-related parameters in erythrocytesGSH-GSSH ratio, antioxidant enzymes and malondialdehyde and plasma FRAP ferric reducingability of plasma, and levels of 8-isoprostane, vitamins C and E were measured at baseline and aftertreatment. Following administration of vitamins C+E, patients with EH had significantly lowersystolic BP, diastolic BP and mean arterial BP and higher erythrocyte and serum antioxidant capacitycompared with either placebo-treated patients with EH or the patients with EH at baseline priorto treatment. BP correlated positively with plasma 8-isoprostane levels and negatively with plasmaFRAP levels in the vitamins C+E- and placebo-treated groups. In conclusion, the present studysupports the view that oxidative stress is involved in the pathogenesis of EH, and that enhancementof antioxidant status by supplementation with vitamins C and E in patients with EH is associatedwith lower BP. This suggests intervention with antioxidants as an adjunct therapy for hypertension.



Author: Rodrigo Salinas, Ramón; - Prat Martorell, Hernán; - Araya, Julia; - Passalacqua Rivanera, Walter; - Bachler, Jean P.; -

Source: http://repositorio.uchile.cl/



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