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BMC Research Notes

, 4:268

First Online: 29 July 2011Received: 12 April 2011Accepted: 29 July 2011DOI: 10.1186-1756-0500-4-268

Cite this article as: Weerakoon, K.G., Kularatne, S.A., Edussuriya, D.H. et al. BMC Res Notes 2011 4: 268. doi:10.1186-1756-0500-4-268

Abstract

BackgroundIn 2009, an outbreak of dengue caused high fatality in Sri Lanka. We conducted 5 autopsies of clinically suspected myocarditis cases at the General Hospital, Peradeniya to describe the histopathology of the heart and other organs.

MethodsThe diagnosis of dengue was confirmed with specific IgM and IgG ELISA, HAI and RT-PCR techniques. The histology was done in tissue sections stained with hematoxylin and eosin.

ResultsOf the 319 cases of dengue fever, 16652% had severe infection. Of them, 149 patients 90% had secondary dengue infection and in 5 patients, DEN-1 was identified as the causative serotype. The clinical diagnosis of myocarditis was considered in 4527% patients. The autopsies were done in 5 patients who succumbed to shock 3 females and 2 males aged 13- 31 years. All had pleural effusions, ascites, bleeding patches in tissue planes and histological evidence of myocarditis. The main histological findings of the heart were interstitial oedema with inflammatory cell infiltration and necrosis of myocardial fibers. One patient had pericarditis. The concurrent pulmonary abnormalities were septal congestion, pulmonary haemorrhage and diffuse alveolar damage; one case showed massive necrosis of liver.

ConclusionsThe histology supports occurrence of myocarditis in dengue infection.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-4-268 contains supplementary material, which is available to authorized users.

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Autor: Kosala GAD Weerakoon - Senanayake AM Kularatne - Deepthika H Edussuriya - Sarachchandra KA Kodikara - Laxman PG Gunatila

Fuente: https://link.springer.com/







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