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BMC Cancer

, 11:320

Genetics, genomics and epigenetics

Abstract

BackgroundCD133 is known to be a cancer stem cell CSC marker. However, recent studies have revealed that CD133 is not restricted to CSC but to be expressed not only in human normal tissues but also in some cancers and could serve as a prognostic factor for the patients. Nevertheless, the expression of CD133 in human cholangiocarcinoma CC is rare and our study is to detect the expression and explore the potential functions of CD133 in human CC.

MethodsFifty-nine cases, comprised of 5 normal liver tissues and 54 consecutive CC specimens 21 well-differentiated, 12 moderately-differentiated and 21 poorly-differentiated, were included in the study. Immunohistochemical stainning with CD133 protein was carried out, and statistical analyses were performed.

ResultsCD133 was found to express in all 5 normal livers and 40 out of 54 74% CC tissues with different subcellular localization. In the well, moderately and poorly differentiated cases, the numbers of CD133 positive cases were 19 19 of 21, 90%, 10 10 of 12, 83% and 11 11 of 21, 52% respectively. Further statistical analyses indicated that the expression and different subcellular localization of CD133 were significantly correlated with the differentiation status of tumors P = 0.004, P = 0.009. Among 23 patients followed up for survival, the median survival was 4 months for fourteen CD133 negative patients but 14 months for nine CD133 positive ones. In univariate survival analysis, CD133 negative expression correlated with poor prognosis while CD133 positive expression predicted a favorable outcome of CC patients P = 0.001.

ConclusionsOur study demonstrates that CD133 expression correlates with the differentiation of CC and indicates that CD133 is a potential indicator for differentiation and prognosis of human CC.

KeywordsCD133 Cholangiocarcinoma Immunohistochemistry Differentiation Prognosis AbbreviationsCSCcancer stem cell

CCcholangiocarcinoma

ICCintrahepatic cholangiocarcinoma

HCChilar cholangiocarcinoma

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-11-320 contains supplementary material, which is available to authorized users.

Linni Fan, Furong He contributed equally to this work.

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Autor: Linni Fan - Furong He - Hongxiang Liu - Jin Zhu - Yixiong Liu - Zhiyong Yin - Lu Wang - Ying Guo - Zhe Wang - Qingguo Ya

Fuente: https://link.springer.com/



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