Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytesReportar como inadecuado




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Cellular and Molecular Life Sciences

, Volume 68, Issue 15, pp 2525–2538

First Online: 06 May 2011Received: 15 January 2011Revised: 01 April 2011Accepted: 12 April 2011DOI: 10.1007-s00018-011-0690-x

Cite this article as: Steinbusch, L.K.M., Schwenk, R.W., Ouwens, D.M. et al. Cell. Mol. Life Sci. 2011 68: 2525. doi:10.1007-s00018-011-0690-x

Abstract

Cardiomyocytes use glucose as well as fatty acids for ATP production. These substrates are transported into the cell by glucose transporter 4 GLUT4 and the fatty acid transporter CD36. Besides being located at the sarcolemma, GLUT4 and CD36 are stored in intracellular compartments. Raised plasma insulin concentrations and increased cardiac work will stimulate GLUT4 as well as CD36 to translocate to the sarcolemma. As so far studied, signaling pathways that regulate GLUT4 translocation similarly affect CD36 translocation. During the development of insulin resistance and type 2 diabetes, CD36 becomes permanently localized at the sarcolemma, whereas GLUT4 internalizes. This juxtaposed positioning of GLUT4 and CD36 is important for aberrant substrate uptake in the diabetic heart: chronically increased fatty acid uptake at the expense of glucose. To explain the differences in subcellular localization of GLUT4 and CD36 in type 2 diabetes, recent research has focused on the role of proteins involved in trafficking of cargo between subcellular compartments. Several of these proteins appear to be similarly involved in both GLUT4 and CD36 translocation. Others, however, have different roles in either GLUT4 or CD36 translocation. These trafficking components, which are differently involved in GLUT4 or CD36 translocation, may be considered novel targets for the development of therapies to restore the imbalanced substrate utilization that occurs in obesity, insulin resistance and diabetic cardiomyopathy.

KeywordsCardiac metabolism Intracellular traffic GLUT4 CD36 Insulin resistance Diabetes  Download fulltext PDF



Autor: Laura K. M. Steinbusch - Robert W. Schwenk - D. Margriet Ouwens - Michaela Diamant - Jan F. C. Glatz - Joost J. F. P

Fuente: https://link.springer.com/







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