Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-upReportar como inadecuado




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BMC Cancer

, 11:431

First Online: 07 October 2011Received: 15 April 2011Accepted: 07 October 2011DOI: 10.1186-1471-2407-11-431

Cite this article as: Grundmark, B., Zethelius, B., Garmo, H. et al. BMC Cancer 2011 11: 431. doi:10.1186-1471-2407-11-431

Abstract

BackgroundSerum selenium level s-Se has been associated with prostate cancer PrCa risk. We investigated the relation between s-Se, smoking and non-screening detected PrCa and explored if polymorphisms in two DNA repair genes: OGG1 and MnSOD, influenced any effect of s-Se.

MethodsULSAM, a population based Swedish male cohort n = 2322 investigated at age 50 for s-Se and s-Se influencing factors: serum cholesterol, erythrocyte sedimentation rate and smoking habits. At age 71 a subcohort, n = 1005 was genotyped for OGG1 and MnSOD polymorphisms.

ResultsIn a 34-year-follow-up, national registries identified 208 PrCa cases further confirmed in medical records. Participants with s-Se in the upper tertile had a non-significantly lower risk of PrCa. Smokers with s-Se in the two lower tertiles ≤80 μg-L experienced a higher cumulative incidence of PrCa than smokers in the high selenium tertile Hazard Ratio 2.39; 95% CI: 1.09-5.25. A high tertile selenium level in combination with non-wt rs125701 of the OGG1 gene in combination with smoking status or rs4880 related variation of MnSOD gene appeared to protect from PrCa.

ConclusionsS-Se levels and smoking habits influence long-term risk of PrCa. Smoking as a risk factor for PrCa in men with low s-Se is relevant to explore further. Exploratory analyses of variations in OGG1 and MnSOD genes indicate that hypotheses about patterns of exposure to selenium and smoking combined with data on genetic variation in genes involved in DNA repair can be valuable to pursue.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-11-431 contains supplementary material, which is available to authorized users.

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Autor: Birgitta Grundmark - Björn Zethelius - Hans Garmo - Lars Holmberg

Fuente: https://link.springer.com/







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