Current views on the role of Notch signaling and the pathogenesis of human leukemiaReportar como inadecuado




Current views on the role of Notch signaling and the pathogenesis of human leukemia - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 11:502

BMC Cancer-s 10th anniversary special edition

Abstract

The Notch signaling pathway is highly conserved from Drosophila to humans and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis.

Constitutive activation of Notch signaling has been shown to result in excessive cellular proliferation and a wide range of malignancies, including leukemia, glioblastoma and lung and breast cancers. Notch can also act as a tumor suppressor, and its inactivation has been associated with an increased risk of spontaneous squamous cell carcinoma. This minireview focuses on recent advances related to the mechanisms and roles of activated Notch1, Notch2, Notch3 and Notch4 signaling in human lymphocytic leukemia, myeloid leukemia and B cell lymphoma, as well as their significance, and recent advances in Notch-targeted therapies.

AbbreviationsILinterleukin

NF-κΒnuclear factor κΒ.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-11-502 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Joanna Pancewicz - Christophe Nicot

Fuente: https://link.springer.com/







Documentos relacionados