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BMC Cancer

, 11:501

BMC Cancer-s 10th anniversary special edition

Abstract

Molecular classification has added important knowledge to breast cancer biology, but has yet to be implemented as a clinical standard. Full sequencing of breast cancer genomes could potentially refine classification and give a more complete picture of the mutational profile of cancer and thus aid therapy decisions. Future treatment guidelines must be based on the knowledge derived from histopathological sub-classification of tumors, but with added information from genomic signatures when properly clinically validated. The objective of this article is to give some background on molecular classification, the potential of next generation sequencing, and to outline how this information could be implemented in the clinic.

AbbreviationsaCGHarray comparative genomic hybridization

CNAcopy number alterations

HRhomologous recombination

PARPpoly ADP ribose polymerase

PCRpolymerase chain reaction.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-11-501 contains supplementary material, which is available to authorized users.

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Autor: Hans Kristian Moen Vollan - Carlos Caldas

Fuente: https://link.springer.com/







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