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Purinergic Signalling

, Volume 7, Issue 4, pp 393–402

First Online: 27 July 2011Received: 31 May 2011Accepted: 11 July 2011DOI: 10.1007-s11302-011-9250-y

Cite this article as: Cieślak, M., Kukulski, F. & Komoszyński, M. Purinergic Signalling 2011 7: 393. doi:10.1007-s11302-011-9250-y

Abstract

Extracellular nucleotides and adenosine play important roles in inflammation. These signaling molecules interact with the cell-surface-located P2 and P1 receptors, respectively, that are widely distributed in the central nervous system and generally exert opposite effects on immune responses. Indeed, extracellular ATP, ADP, UTP, and UDP serve as alarmins or damage-associated molecular patterns that activate mainly proinflammatory mechanisms, whereas adenosine has potent anti-inflammatory and immunosuppressive effects. This review discusses the actual and potential role of extracellular nucleotides and adenosine in multiple sclerosis MS.

KeywordsNeuroinflammation Demyelination Autoimmune encephalomyelitis P2 receptor P1 receptor  Download fulltext PDF



Autor: Marek Cieślak - Filip Kukulski - Michał Komoszyński

Fuente: https://link.springer.com/



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