Angiogenesis Markers Quantification in Breast Cancer and Their Correlation with Clinicopathological Prognostic VariablesReportar como inadecuado




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Pathology and Oncology Research

, Volume 17, Issue 4, pp 809–817

First Online: 11 May 2011Received: 02 September 2010Accepted: 09 March 2011DOI: 10.1007-s12253-011-9387-6

Cite this article as: Rykala, J., Przybylowska, K., Majsterek, I. et al. Pathol. Oncol. Res. 2011 17: 809. doi:10.1007-s12253-011-9387-6

Abstract

Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule ICAM-1, keratinocyte growth factor KGF, platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels of Ang-2, PDGF-BB, bFGF, ICAM-1 and VEGF in patients with breast cancer compared to the benign breast diseases patients. Moreover, some of these angiogenesis markers evaluated in tumour and serum of breast cancer patients exhibited association with standard clinical parameters, ER status as well as MVD of tumours. Angiogenesis markers play important roles in tumour growth, invasion and metastasis. Our results suggest that analysis of angiogenesis markers in tumour and serum of breast cancer patients using multiplex protein assay can improve diagnosis and prognosis in this diseases.

KeywordsBreast cancer Angiogenesis Cancer progression Multiplex protein assay  Download fulltext PDF



Autor: Jan Rykala - Karolina Przybylowska - Ireneusz Majsterek - Grazyna Pasz-Walczak - Andrzej Sygut - Adam Dziki - Julia Kruk-Je

Fuente: https://link.springer.com/







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