The relationship between basal and squamous cell skin cancer and smoking related cancersReport as inadecuate

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BMC Research Notes

, 4:556

First Online: 22 December 2011Received: 19 July 2011Accepted: 22 December 2011DOI: 10.1186-1756-0500-4-556

Cite this article as: Sitas, F., Yu, X.Q., O-Connell, D.L. et al. BMC Res Notes 2011 4: 556. doi:10.1186-1756-0500-4-556


BackgroundWe compared the risk of being diagnosed with smoking-related cancers lung, oral cavity, upper digestive and respiratory organs, bladder, kidney, anogenital cancers and myeloid leukaemia among people with squamous cell carcinoma SCC or basal cell carcinoma of the skin BCC, with risks found in the general population using data from an Australian population-based cancer registry.

MethodsPeople diagnosed with BCC or SCC in 1980-2003 reported to the Tasmanian Cancer Registry, Australia, were followed-up by linkage within the registry, until diagnosis of a subsequent smoking-related cancer, death, or until 31 December 2003. Risk of developing a future smoking-related cancer was assessed using age Standardised Incidence Ratios SIR.

ResultsPeople diagnosed with SCC had an increased risk of lung cancer men: SIR = 1.89, 95% confidence interval: 1.61-2.21; women: SIR = 2.04, 1.42-2.83 and all other smoking-related cancers men: SIR = 1.38, 1.19-1.60; women: SIR = 1.78, 1.34-2.33. Men with BCC had a significant increased risk of lung cancer SIR = 1.26, 1.10-1.44 but not of any of the other smoking-related cancers SIR = 1.09, 0.97-1.23.

ConclusionsIndividuals with a history of SCC having an increased risk of developing smoking related cancers cancer suggests smoking as a common etiology. The relationship between BCC and smoking-related cancers is less certain.

AbbreviationsBCCBasal Cell skin cancer

AERAbsolute excess risk

CIconfidence interval

NHLnon-Hodgkin lymphoma

NMSCNon-melanoma skin cancer

SCCSquamous cell skin cancer

SIRStandardised incidence ratio

TCRTasmanian Cancer Registry


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Author: Freddy Sitas - Xue Qin Yu - Dianne L O-Connell - Leigh Blizzard - Petr Otahal - Leah Newman - Alison Venn



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