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Journal of Molecular Modeling

, Volume 18, Issue 2, pp 607–609

First Online: 11 May 2011Received: 10 February 2011Accepted: 29 March 2011DOI: 10.1007-s00894-011-1081-9

Cite this article as: Kuhn, C. J Mol Model 2012 18: 607. doi:10.1007-s00894-011-1081-9


The concept called Knowledge is a measure of the quality of genetically transferred information. Its usefulness is demonstrated quantitatively in a Monte-Carlo simulation on critical steps in a origin of life model. The model describes the origin of a bio-like genetic apparatus by a long sequence of physical-chemical steps: it starts with the presence of a self-replicating oligomer and a specifically structured environment in time and space that allow for the formation of aggregates such as assembler-hairpins-devices and, at a later stage, an assembler-hairpins-enzyme device—a first translation machine.

KeywordsAssembler-hairpins-enzyme device Emergence and storage of information Genetic apparatus Knowledge Monte-Carlo Origin of life Structured time-space environment Electronic supplementary materialThe online version of this article doi:10.1007-s00894-011-1081-9 contains supplementary material, which is available to authorized users.

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Autor: Christoph Kuhn


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